If the discomfort becomes severe or troublesome, discuss it with your doctor, as a corticosteroid cream can be prescribed to help ease the reaction. It works by killing fast growing skin cells. Best Pain Soother During Efudex Treatment Simplicite Skin Care Most patients use the cream twice a day for 4 weeks from start to finish. Does fluorouracil cream really work . Chemotherapy cream is a topical ointment or cream that a person applies to the skin. Accordingly, an 85% sustained cure rate was observed. • fluorouracil cream may damage sperm and may harm the baby if used during pregnancy. No symptoms as yet that i can tell, but at the end of dec my dermatologist used liquid nitrogen of=n several areas on my back and on both m arms and backs of my hands where she thought cancel may develope if left untreated. These effects are normal and show that the fluorouracil is working. It is best to use birth control while being treated with fluorouracil. Fluorouracil is most ...